bioRxivJClub
Spatial transcriptomics reveals organizational properties of the mouse spinal cord and alterations in neuropathic pain
bioRxiv · · Preprint · Open access
Wang, Hu + 9 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Spatially resolved single-cell transcriptomics in adult mouse spinal cord maps distinct laminar and spatial distributions of neuronal subtypes, including axial level and sex-specific differences.
- Why it matters: The spinal cord’s circuit logic depends on where cell types sit and how they communicate, but spatial organization and neuropathic pain–linked changes are not well resolved.
- What they did: They profiled adult mouse spinal cord with spatially resolved single-cell transcriptomics, then assessed predicted cell-cell communication using spatial patterns of neuropeptide and ligand-receptor pairs.
- The result: Neuronal subtypes show close spatial proximity and dorsal-horn communication motifs, and several neuronal subtypes display altered transcriptomic profiles and predicted communications in a neuropathic pain model.
The findingWhy it mattersWhat they didThe result
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- Open access
- 5 cites