ALKBH5-driven epitranscriptomic changes in cancer-associated fibroblasts promote pancreatic cancer metastasis independently of primary tumor growth.
- Open access
Chromatin Remodeling and Cancer
Moving in bioRxiv, Cancer Research, medRxiv, Nature Chemical Biology, Cancer Cell, Cancer Discovery, EMBO Journal, Frontiers in Genetics.
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Latest in Chromatin Remodeling and Cancer
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High-risk rhabdomyosarcomas share a common neural-like cell state, regardless of FOXO1 fusion status, revealing a convergent transcriptional phenotype in lethal cases.
- Open access
MutationProjector, a cancer genotype foundation model, accurately predicts therapeutic resistance and sensitivity across multiple cancer types, surpassing existing methods in all tested contexts.
- Open access
Monovalent degraders can recruit two E3 ligases simultaneously to degrade SMARCA2/4, with tunable dependency on DCAF16 or FBXO22.
- Open access
- 2 cites
SAGA and ATAC co-activator complexes use distinct strategies to regulate gene transcription, with implications for cancer therapy.
- Open access
BRD9 degradation enhances GBAF chromatin remodeling activity in synovial sarcoma, undermining therapeutic efforts with minimal impact on tumor proliferation.
- Open access
SMARCB1-deficient tumors are highly sensitive to H3K27 demethylase inhibitors, with GSK-J4 suppressing tumor growth in patient-derived models.
Looplook accurately assigns target genes by integrating 3D chromatin topology with functional genomics, outperforming traditional methods in liposarcoma cells.
- Open access
BACH1 acts as a pioneer repressor, priming chromatin and regulating macrophage plasticity with 3D architecture constraints, crucial for tissue adaptation and inflammation responses.
- Open access
- 3 cites
Histone tail mutants reveal key roles of chromatin in development and disease, with over 100 variants enabling direct functional analysis of chromatin marks.
Embryonic stem cells exhibit similar higher-order chromatin fibre structures to differentiated cells, with only slight differences, challenging the idea of an "open" chromatin state.
- Open access
- 1 cites
Deep learning accurately predicts mutations, treatment response, and recurrence risk in 8,398 gastrointestinal stromal tumor cases, with AUCs up to 0.96 for key mutations.
- Open access
GDF15-driven remodeling of the liver microenvironment promotes uveal melanoma metastasis, with silencing of GDF15 reducing metastatic growth in models.
- Open access
Menin is essential for normal megakaryopoiesis and represents a therapeutic target in myeloproliferative neoplasms, with its inhibition causing severe thrombocytopenia.
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