Research area · week to 3 Oct 2026

Cancer, Lipids, and Metabolism

Moving in bioRxiv, Cancer Research, Nature Cancer, Cancer Discovery, Cell Metabolism, Cell Reports, eLife, Environmental pollution.

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PDE5A Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking through a Noncanonical cGMP-Dependent Pathway.
Cancer Research · 2 Oct 2026 · Journal Article
PDE5a inhibitors like sildenafil reduce cancer metastasis by disrupting NPC1-mediated cholesterol trafficking, causing lysosomal cholesterol accumulation and impairing cell migration.
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https://jclub.com.au/a/42446922
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Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment activates p300, causing a 50% reduction in PARPi effectiveness in epithelial ovarian cancer.
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https://jclub.com.au/a/42467549
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Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.
Cancer Discovery · 1 Oct 2026 · Journal Article
Dietary unsaturated fatty acids differentially influence pancreatic cancer progression by modulating ferroptosis sensitivity, with MUFAs promoting and PUFAs inhibiting tumor development.
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https://jclub.com.au/a/42053430
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Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.19.712341
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β3-Integrin controls pericyte metabolic states and shapes tumour-stromal metabolic crosstalk in breast cancer
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.751368
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ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesisand fatty acid oxidation in colorectal cancer
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753323
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Population-scale plasma proteomics reveals pre-diagnostic biomarkers and shared pathways of cancer risk across 25 cancers
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363676
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Suppression of de novo lipogenesis and dietary PUFA supplementation inhibit prostate cancer progression
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.25.714193
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Zonated cholesterol sensing by SIRT2 drives MASLD-HCC.
Cell Metabolism · 17 Sept 2026 · Journal Article
Zonated cholesterol sensing by SIRT2 initiates MASLD-related hepatocellular carcinoma, with SIRT2 overexpression in zone 1 causing tumors in mice and humans.
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Targeting valine metabolism and ferroptosis to overcome chemoresistance in PDAC.
Nature Cancer · 14 Sept 2026 · Journal Article
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Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity.
Nature Cancer · 1 Sept 2026 · Journal Article
Targeting PID1 in tumor-associated macrophages produces oxysterols that reprogram macrophages toward an antitumor phenotype, enhancing immune responses in multiple cancers.
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Comment on "Serum procalcitonin: A novel tumor biomarker for … fibrolamellar hepatocellular carcinoma".
Journal of hepatology · 1 Sept 2026 · Letter
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https://jclub.com.au/a/41759963
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Steatosis fuels replacement liver metastases in colorectal cancer.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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Implications of the 2026 Dyslipidemia Guideline for Primary Prevention Statin Therapy.
JAMA · 18 Aug 2026 · Comparative Study
The 2026 dyslipidemia guideline increases US primary prevention statin eligibility to 87.5 million adults, mainly in lower-risk, younger populations.
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Increasing Cancer Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.27.650697
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Bisphenol A-mediated GPER1/PPARγ/ACC/FAS signaling induces de novo lipogenesis and lipid accumulation in luminal and triple-negative breast cancer cells to regulate epithelial-mesenchymal plasticity.
Environmental pollution · 14 Aug 2026 · Journal Article
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Stearoyl-CoA desaturases regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance.
Cell Reports · 10 Aug 2026 · Journal Article
Stearoyl-CoA desaturases are essential for intestinal stem cell function, with their inhibition reducing stem cell proliferation and impairing tissue regeneration in mice.
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https://jclub.com.au/a/42579558
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Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis.
eLife · 5 Aug 2026 · Journal Article
Arginine restriction in pancreatic tumors impairs lipid synthesis and increases vulnerability to polyunsaturated fatty acids, leading to ferroptosis.
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