bioRxivJClub
Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics
bioRxiv · · Preprint · Open access
Barahtjan, Cook + 14 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Disrupting lipid asymmetry in mammalian cells by knocking out flippases, floppases, and scramblases elevates neutral lipid and ATP consumption while increasing heat loss per unit biomass despite slower growth.
- Why it matters: Lipid trans-bilayer gradients are linked to many cellular processes, but how dysregulation of lipid asymmetry reshapes cellular energetics is unclear.
- What they did: The authors systematically mapped affected processes in mammalian cells using lipidomics, respirometry, lipid/metabolic imaging, and live-cell calorimetry after gene knockouts of lipid transporters.
- The result: The findings connect active lipid asymmetry maintenance to cellular energetics, suggesting an energetic strain that shifts cells toward a more energy-using catabolic state.
The findingWhy it mattersWhat they didThe result
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- Open access
- 6 cites