eLifeJClub
Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments.
eLife · · Journal Article · Open access
Chang, Bin Munim + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Some cancer cells raise the NAD+/NADH ratio during serine deprivation by increasing mitochondrial respiration, enabling higher serine production and proliferation in serine-limiting conditions.
- Why it matters: The NAD+/NADH ratio can limit biomass synthesis and proliferation under nutrient stress, but the cellular processes that regulate it during deprivation are unclear.
- What they did: The study measured how cancer cells respond to serine deprivation, linking mitochondrial respiration changes to shifts in NAD+/NADH and downstream serine synthesis and growth, with effects assessed independently of serine synthesis enzyme expression.
- The result: Cells that increase mitochondrial respiration show higher serine production and proliferation under serine limitation, and mitochondrial respiration–driven NAD+/NADH increases promote serine synthesis even when serine is not environmentally limiting.
The findingWhy it mattersWhat they didThe result
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- Open access
- 2 cites