Acidic tumor microenvironment activates p300, causing a 50% reduction in PARPi effectiveness in epithelial ovarian cancer.
Cancer, Hypoxia, and Metabolism
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MYC drives tissue-specific and systemic metabolic reprogramming in tumors, creating context-dependent vulnerabilities that can be targeted for therapy.
Nuclear OXCT1 reduces histone β-hydroxybutyrylation at MHC-I loci, decreasing immune gene transcription and impacting hepatocellular carcinoma response to immunotherapy.
Loss of KDM6A enhances oxidative phosphorylation across multiple tissues, revealing a conserved mechanism of tissue-level convergent evolution in cancer and development.
- Open access
Loss of MTAP in pancreatic ductal adenocarcinoma (PDAC) increases BCAT1 expression by DNA demethylation, leading to a 2.5-fold BCAA dependency that promotes tumor progression.
- Open access
Cancer cells inactivate the mitochondrial tumor suppressor LACTB through enhanced autoproteolysis mediated by MRPS34 in breast cancers.
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Canonical Notch2 signaling is essential for the development, maintenance, and function of iron-recycling macrophages, with its disruption causing iron overload in mice.
- Open access
An iron-dependent methionine redox pathway controls adipose browning and cachexia, with MsrA deletion reducing cachexia and extending survival in mouse models.
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ACLY palmitoylation driven by palmitic acid enhances macrophage histone acetylation, suppressing hepatocellular carcinoma progression by reprogramming the tumor microenvironment.
- Open access
Acetate inhibits esophageal squamous cell carcinoma growth by activating an ACSS2-dependent H2A.Z acetylation pathway, with low acetate and ACSS2 linked to poor prognosis.
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Inhibiting autophagy with ATG7 silencing nanoparticles enhances radiotherapy effectiveness in high-grade mutant IDH1 gliomas, leading to tumor regression and long-term survival.
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IDH3A-driven citrate accumulation controls metabolic fitness and venetoclax resistance in AML stem cells, with knockdown impairing leukemia maintenance.
NDST2-driven N-glycosylation of EGFR at four conserved sites promotes lenvatinib resistance in hepatocellular carcinoma, with NDST2 upregulation correlating with resistance.
Loss of LDHA in breast cancer cells disrupts R-loop homeostasis, causing increased R-loop accumulation and DNA damage, with 199 peaks rising and 81 decreasing.
- Open access
Macrophages transfer intact cancer cell surface proteins to their surface during live-cell uptake, significantly altering their proteome without transcriptional changes.
- Open access
- 1 cites
Lactate-activated GPR132 signaling promotes kidney cancer growth by sustaining mitochondrial function and lactate uptake, with GPR132 blockade impairing tumor progression.
Lactate-α-ketoglutarate metabolic circuit in tumor-infiltrating Treg cells promotes tumor progression by inducing NK cell senescence, with GDH1 as a key driver.
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