Semaglutide improves liver health in mice with MASH through intrahepatic sinusoidal endothelial GLP-1 receptors, independent of weight loss, with a substantial effect on fibrosis and immune remodeling.
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Cell Metabolism
Cell Press · Cell & Molecular Biology · ISSN 1550-4131, 1932-7420
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Gut microbial enzyme AdhE degrades metformin, reducing its effectiveness in treating type 2 diabetes, especially in low-responders, by lowering systemic drug levels.
Lactate-induced K63 lactylation of RIPK3 drives necroptosis, with 50% reduction in cell death observed in mouse models of injury and infection.
Obesity reduces adipose ILC2s by decreasing ACC1, impairing their function and promoting metabolic inflammation in mice.
Adipocytes function as active immune cells, recognizing pathogens and producing antimicrobial peptides, thus playing a crucial role in host defense.
Liver dysfunction impairs selenium delivery to cartilage, promoting osteoarthritis in mice and humans, with a 20% higher prevalence in liver disease patients.
Hepatic glutamine metabolism critically regulates pathogenic CD4(+) T cell inflammation, with Gln depletion linked to increased liver damage in MASLD.
- Open access
Zonated cholesterol sensing by SIRT2 initiates MASLD-related hepatocellular carcinoma, with SIRT2 overexpression in zone 1 causing tumors in mice and humans.
Blocking PD-L2 reduces senescent cell accumulation by 50% in aged mice, improving insulin sensitivity and physical strength, highlighting a new target for age-related dysfunction.
Renaming polyendocrine metabolic ovarian syndrome highlights its core metabolic dysfunction, emphasizing its link to increased cardiovascular and metabolic disease risks in millions of women.
GLP-1 receptor agonists improve fertility-related issues in women with polyendocrine metabolic ovarian syndrome by targeting complex endocrine disturbances.
Aging reduces hepatic β-hydroxybutyrate synthesis, causing CD8+ T cell exhaustion and impairing antitumor and antiviral immunity in aged hosts.
Competitive catabolism of fatty acids and glucose in obesity causes hyperglycemia and hyperinsulinemia, driven by a physiological circuit identified through modeling.
FGF21 combined with leptin reverses hepatic leptin resistance, offering a potent therapy for obesity-related metabolic disorders in mice and human tissues.
Hyocholic acids dominate neonatal bile acids, constituting over 51% in meconium and shaping immune development during early life.
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- 1 cites
Lactate inhibits STING activation by upregulating LDHA activity, promoting tumor immune evasion in cancer.
Hyocholic acids in early life promote beneficial microbiota colonization and immune regulation, establishing a critical window for immune development.
Single-cell multiomics analysis of over four million human pancreatic cells uncovers fetal-like plasticity in adult centroacinar-like cells and lineage dynamics across development and disease.
Brown adipose tissue reduces hepatic oxidative stress by releasing 3-hydroxystearic acid, a cold-induced metabolite that modulates liver mitochondrial function.
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