A bedside-to-outside model of human nutrition research.

The bedside-to-outside model combines controlled feeding and free-living studies within one cohort to assess dietary interventions' efficacy and effectiveness simultaneously.

• Why it matters: Understanding actual human eating behavior in real-world conditions is challenging, limiting the translation of controlled dietary research into practical health outcomes.
• What they did: Researchers developed a model that integrates controlled feeding studies with free-living intervention studies in the same cohort to enable causal inference about dietary impacts.
• The result: This approach allows for direct comparison of efficacy and effectiveness of dietary interventions, providing novel insights into their real-world impact.

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