Neutrophil-integrated syncytial CAR macrophages significantly enhance tumor infiltration and therapeutic efficacy, reducing tumor burden and preventing recurrence in mouse models.
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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Latest in Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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Elevated reactive oxygen species induce Paneth cell dedifferentiation and reduce antimicrobial function, impairing intestinal innate immunity during inflammation.
- Open access
Senescent-like neutrophils expressing BHLHE40 promote immunosuppressive and angiogenic niches in colorectal cancer liver metastasis, correlating with poor prognosis.
Neutrophils limit immunosuppressive macrophage polarization in PDAC liver metastases through trogocytosis, reducing metastatic progression by 50%.
- Open access
Membrane vesicles are crucial biofilm matrix components in Staphylococcus aureus, significantly enhancing biofilm formation by carrying DNA and other matrix elements.
- Open access
Neutrophils predominantly promote tumor growth and metastasis in cancer, but can also mediate tumor cell killing depending on environmental cues.
Retinoic acid promotes expansion of CD177+ neutrophils that drive steroid-resistant GI-GVHD, with RA receptor inhibition restoring steroid sensitivity in models.
- Open access
NADPH oxidases (NOXs) are key regulators of immune, metabolic, and environmental signals, with recent studies revealing their structures, regulatory mechanisms, and roles in disease, especially in immune and tumor contexts.
- Open access
The G2019S mutation in LRRK2 enhances NADPH oxidase-2 activity in neutrophils, improving bacterial infection control in mice by 2- to 3-fold.
Mitiperstat, an MPO inhibitor, did not improve symptoms or exercise capacity in 711 patients with heart failure and preserved or mildly reduced ejection fraction over 48 weeks.
Six prognostic genes related to NETosis and inflammation, including CXCL13 and IL12B, were identified to predict breast cancer outcomes with a moderate accuracy model.
- Open access
Distinct NADPH oxidases in Arthrobotrys flagrans coordinate cell fusion and prey capture through spatially compartmentalized ROS signaling.
- Open access
Candida spp. suppress neutrophil reactive nitrogen species below basal levels during infection, aiding fungal evasion and survival in host organisms.
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