The abstract is read at the publisher; the summary is JClub's.
COVID-19 and active tuberculosis show distinct maturation-associated neutrophil transcriptional programs, with 45.2% of 770 curated genes differing in response magnitude between diseases.
- Why it matters: Neutrophils can either control pathogens or drive damaging lung inflammation, but it is unclear which transcriptional programs underlie these divergent roles across pulmonary infections.
- What they did: The study integrated six whole-blood bulk RNA-seq datasets (three COVID-19, three active TB), applied ComBat-Seq for batch adjustment, and used DESeq2 to test differential expression versus disease-appropriate controls across a 770-gene panel.
- The result: COVID-19 had reduced CD10 (MME) and CD16 (FCGR3A) with higher MPO and ELANE and other NET-associated genes, while TB showed higher maturation, receptor, oxidative, and recruitment responses; maturation signatures were most reproducible (100% and 90% concordance).
The findingWhy it mattersWhat they didThe result
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