Research area · week to 3 Oct 2026

Cancer-related molecular mechanisms research

Moving in bioRxiv, Biotechnology advances, Blood, Cell Reports, eLife, Frontiers in Genetics, medRxiv, Nature.

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Accurate isoform quantification in bulk and single-cell RNA-seq by integrating multi-platform sequencing data and sequence-to-expression models
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.07.11.603067
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Disruption of NUAK2-Mediated RNA Splicing by Trilaciclib Reveals a Therapeutic Vulnerability in AR-Indifferent Prostate Cancer
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.12.687734
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Direct and indirect regulation of fetal globin transcript by the RNA-binding protein IGF2BP1.
Blood · 24 Sept 2026 · Journal Article
IGF2BP1 directly binds HBG1/2 transcripts and activates HIC2, revealing a dual mechanism regulating fetal hemoglobin expression.
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https://jclub.com.au/a/42341077
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The regulation of COX-2, ABCA1, and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis.
Cell Reports · 22 Sept 2026 · Journal Article
PACERR lncRNA regulates COX-2, ABCA1, and ABCG1, linking inflammation and cholesterol homeostasis in vascular and immune cells.
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https://jclub.com.au/a/42696452
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A B1 SINE element within the mouse Malat1 long noncoding RNA acts as an internal ribosome entry site mediating micropeptide translation
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.11.705401
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Waking the sleepers: lincRNA overexpression compromises DHX36 activity and global protein synthesis
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.28.735068
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Facilitating genome annotation using ANNEXA and long-read RNA sequencing
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.16.648718
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A deep generative decoder predicts microRNA expression from bulk and single-cell mRNA profiles
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.727918
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Identification and Characterization of PCAHIT, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.21.655369
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A shared RNA structural element mediates hnRNP K binding by two divergent lncRNAs in the DNA damage response
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.24.666508
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Consistent DNA methylation patterns enable accurate and interpretable cross-platform classification of central nervous system tumors
medRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.07.25337348
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Adding layers of information to scRNA-seq data using pre-trained language models
bioRxiv · 4 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.23.671699
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A Combined Multi-Omics and Supervised Learning Strategy Uncovers an Epithelial Signature of Radiotherapy Response in Colorectal Cancer
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.10.648131
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Hybridization load introduced by Alpine ibex hybrid swarms
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.24.599926
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Detecting and quantifying circular RNAs in terabyte-scale RNA-seq datasets with CIRI3.
Nature Biotechnology · 1 Sept 2026 · Journal Article
CIRI3 detects and quantifies circRNAs in terabyte-scale RNA-seq datasets with ten times greater speed and higher accuracy than existing tools.
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https://jclub.com.au/a/41034498
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A viral coding circRNA contributes to HPV-driven oncogenesis.
Nature Reviews Cancer · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42481735
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Long non-coding RNAs in colorectal cancer: shaping the tumour microenvironment and advancing precision oncology.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Review
Long non-coding RNAs regulate the colorectal cancer microenvironment, influencing tumor progression and resistance, with potential as biomarkers and therapeutic targets.
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https://jclub.com.au/a/42680835
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Confounders of lncRNA screens: sources, consequences and possible solutions.
Nature Methods · 31 Aug 2026 · Journal Article
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https://jclub.com.au/a/42675119
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Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in developing cochlea
bioRxiv · 29 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.01.31.578202
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Mapping genetic regulation of gene expression to cellular contexts identifies long non-coding RNAs associated with brain disorders.
Nature Communications · 29 Aug 2026 · Journal Article
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https://jclub.com.au/a/42806013
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MALAT1 Levels Are Elevated in Thyroid Tumors from Chilean Patients with Lymphatic Infiltration and Are Linked to Metabolic Reprogramming
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.23.696116
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Confound-aware lncRNA genomics: Separating biology from abundance, composition, and temporal artefacts.
Biotechnology advances · 23 Aug 2026 · Review
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https://jclub.com.au/a/42633884
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A genome-wide analysis identifies DIDO3 binding at active chromatin and topological boundaries in mouse stem cells
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2021.09.27.462041
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Cross-cancer transcriptomic analysis reveals conserved developmental, ferroptosis, and immune remodeling modules in Wilms tumor and oral cancer.
Frontiers in Genetics · 17 Aug 2026 · Journal Article
Conserved ferroptosis and immune modules are linked to developmental dysregulation in Wilms tumor, with partial conservation across oral cancer, highlighting potential therapeutic targets.
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https://jclub.com.au/a/42670482
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Long-read RNA sequencing identifies non-coding isoform switching as a regulator of cell fate
bioRxiv · 13 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.02.21.639524
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Aging-associated increase of GATA4 levels in articular cartilage is linked to impaired regenerative capacity of chondrocytes and osteoarthritis.
eLife · 12 Aug 2026 · Journal Article
Aging-related increase in GATA4 levels in chondrocytes accelerates osteoarthritis progression by impairing cartilage regeneration and promoting inflammation.
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https://jclub.com.au/a/42585095
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ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer.
Nature · 5 Aug 2026 · Journal Article
ZFP36L2 is essential for stress-induced dedifferentiation and intestinal regeneration, with its mutation affecting 5-10% of colorectal cancers and influencing metastasis.
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https://jclub.com.au/a/42557330
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