Long non-coding RNAs in colorectal cancer: shaping the tumour microenvironment and advancing precision oncology.

Long non-coding RNAs regulate the colorectal cancer microenvironment, influencing tumor progression and resistance, with potential as biomarkers and therapeutic targets.

• Why it matters: Understanding how lncRNAs shape the tumor microenvironment is crucial because it impacts cancer growth, metastasis, and response to therapy, addressing gaps in targeted treatment strategies.
• What they did: The review analyzes the mechanisms by which lncRNAs modulate immune cells, fibroblasts, and angiogenesis in colorectal cancer, highlighting their dual oncogenic and tumor-suppressive roles across key pathways.
• The result: This work advances knowledge of lncRNA-TME interactions, enabling the development of novel biomarkers and therapies that could improve patient stratification and combat disease progression in colorectal cancer.