Diet and metabolism studies
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Nuclear OXCT1 reduces histone β-hydroxybutyrylation at MHC-I loci, decreasing immune gene transcription and impacting hepatocellular carcinoma response to immunotherapy.
Machine learning predicts 12-week weight-loss response after prolonged fasting using baseline microbiome and clinical data, with key predictors including Faecalibacterium and LDL cholesterol.
- Open access
Competitive catabolism of fatty acids and glucose in obesity causes hyperglycemia and hyperinsulinemia, driven by a physiological circuit identified through modeling.
A very-low-carbohydrate diet yields 2-3 times greater improvements in hepatic insulin sensitivity than Mediterranean or very-low-fat diets during 10% weight loss in metabolically unhealthy obesity.
ALG-055009 significantly reduces liver fat in non-cirrhotic adults with MASH, with up to 33.2% relative decrease at higher doses in a phase 2a trial.
- Open access
Personalized regular meal schedules lead to an average weight loss of 2.10 kg and improved sleep quality in adults with BMI ≥22 kg/m2 over six weeks.
- Open access
- 1 cites
Rapid activation of AgRP neurons by future fasting predictions is driven by PVH Sim2 neurons, revealing a cognitive circuit that anticipates energy deficits in mice.
- Open access
Ketone ester supplementation reduces activation of age-associated B cells in aged mice by 50% without impairing antibody responses.
- Open access
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