JAMA Neurology

AI summary · may contain errors

A single infusion of mivocabtagene autoleucel in antibody-positive adult stiff person syndrome improved timed 25-ft walk at week 16 by a mean of -7.69 seconds (P<.001).

AI summary · may contain errors

RIMKLA-IgG autoantibodies were identified in 8 of 35 patients with inflammatory cerebellar ataxia, most linked to small cell lung cancer (6 of 8).

AI summary · may contain errors

Azetukalner in adults with focal epilepsy reduced median monthly focal seizure frequency by -34.5% with 15 mg and -53.2% with 25 mg versus placebo over 12 weeks.

AI summary · may contain errors

Pooled estimates from 86 population-based studies show infantile-onset epilepsies have a cumulative incidence of 236.0 per 100,000 live births, driven by DEEs.

AI summary · may contain errors

The essay describes a medical student’s experience studying far from her grandmother after she was diagnosed with Alzheimer disease a few years earlier.

AI summary · may contain errors

Delirium within 30 days of hospitalization in cognitively unimpaired adults in the Mayo Clinic Study of Aging is linked to higher incident MCI (aHR 3.67) and dementia (aHR 5.39).

AI summary · may contain errors

Collaborative synergy between neurology and physiatry is proposed as a way to advance science of stroke recovery by aligning two immediate post-stroke treatment perspectives.

AI summary · may contain errors

Solo patients in memory care centers are discussed alongside how caregiver involvement may shape participation in their own care.

AI summary · may contain errors

Portable low-field MRI is evaluated against conventional MRI in memory clinic and community cohorts, using a cohort study design to compare performance.

AI summary · may contain errors

Rapid trio/duo/singleton whole-genome sequencing in pediatric neurology inpatients achieved a 45.1% initial phenotype-concordant diagnostic yield, with faster point-of-care reporting in a tertiary center cohort.

AI summary · may contain errors

Continuous ocrelizumab over 10 years in relapsing multiple sclerosis is linked to a 24% lower hazard of 48-week confirmed disability progression versus delayed initiation.

AI summary · may contain errors

HINTS is most diagnostically effective for acute vestibular syndrome patients with continuous dizziness and spontaneous nystagmus at rest, with accuracy dropping when used in inappropriate populations.

AI summary · may contain errors

CLOSURE-AF and CHAMPION-AF results should guide whether left atrial appendage occlusion is chosen over direct oral anticoagulants for left atrial appendage occlusion in atrial fibrillation.

AI summary · may contain errors

Add-on intravenous immunoglobulin (IVIG) given at 0, 4, and 8 weeks improves myositis activity at week 12 in newly diagnosed adult idiopathic inflammatory myopathies, raising Total Improvement Score to 60.0 vs 42.5 with P=.01.

AI summary · may contain errors

Earlier disclosure of plasma p-tau217 and NfL in a single Spain memory clinic trial increased very high-confidence etiologic Alzheimer diagnosis to 50.0% at 3 months.

AI summary · may contain errors

Hearing aid intervention in older adults with mild cognitive impairment and moderate-to-severe hearing loss did not significantly reduce conversion to dementia-level impairment at 24 months.

AI summary · may contain errors

Administrative work has grown across universities, health care, and research, and a neurology department should evaluate administrative processes using five targeted questions.

AI summary · may contain errors

A harmonized 5-class visual tau PET framework across 18F-MK-6240 and 18F-flortaucipir achieves excellent interrater agreement (κ = 0.77–0.85) and detects more early tau positivity.

AI summary · may contain errors

In a cohort of 1320 adults with Korsakoff syndrome from AP-HP hospitals, 30.2% died over a median 3.1-year follow-up, with mortality linked to malnutrition and older age.

AI summary · may contain errors

The author’s postseizure workups and scans are described as experiences where professional status is linked to a sense of protection on both occasions.

AI summary · may contain errors

Higher exhaled carbon monoxide among never-smokers in the China Kadoorie Biobank is linked to lower Parkinson disease risk, with a dose-dependent adjusted HR down to 0.65 (≥11.5 ppm).