Clinical Characteristics, Neuroimaging Findings, and Mortality in Korsakoff Syndrome.

In a cohort of 1320 adults with Korsakoff syndrome from AP-HP hospitals, 30.2% died over a median 3.1-year follow-up, with mortality linked to malnutrition and older age.

• Why it matters: Evidence on Korsakoff syndrome’s real-world clinical presentation, brain imaging patterns, and long-term survival is limited, leaving clinicians without clear prognostic factors and diagnostic targets.
• What they did: Using electronic health records from August 1, 2017, to December 31, 2022, the study assessed symptoms, comorbidities, and MRI findings, including Papez circuit abnormalities and vascular leukoencephalopathy in 44.4% each.
• The result: During follow-up, 398 patients died; multivariable models associated mortality with malnutrition (HR 1.54), alcoholic liver disease (HR 1.45), male sex (HR 1.45), and age 80 to 89 years (HR 1.89).

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