Left Atrial Appendage Occlusion-Is the Case Now Closed?

CLOSURE-AF and CHAMPION-AF results should guide whether left atrial appendage occlusion is chosen over direct oral anticoagulants for left atrial appendage occlusion in atrial fibrillation.

• Why it matters: Clinicians need evidence to decide between anticoagulant therapy and left atrial appendage closure, but trial findings must be interpreted for real-world treatment choices.
• What they did: This Viewpoint reviews how outcomes from CLOSURE-AF and CHAMPION-AF can be used to inform decision-making between direct oral anticoagulants and left atrial appendage closure.
• The result: The synthesis implies these trials provide the key evidence base for closing the question of which strategy to prefer for left atrial appendage occlusion.

AI summary of the abstract · may contain errors · not medical advice · read the paper.