Effect of diet macronutrient content on the cardiometabolic response to weight loss: A randomized clinical trial.

A very-low-carbohydrate diet yields 2-3 times greater improvements in hepatic insulin sensitivity than Mediterranean or very-low-fat diets during 10% weight loss in metabolically unhealthy obesity.

• Why it matters: Understanding how diet composition influences cardiometabolic health is crucial for optimizing treatment strategies for obesity-related conditions like prediabetes and hepatic steatosis.
• What they did: The study randomized individuals with metabolically unhealthy obesity to three diets—ketogenic, Mediterranean, and plant-based low-fat—and measured changes in insulin sensitivity, liver fat, and metabolic markers after approximately 10% weight loss.
• The result: The very-low-carbohydrate diet significantly improved hepatic insulin sensitivity and reduced liver fat and related metabolic markers more than the other diets, highlighting its potential for targeted cardiometabolic benefits.