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Pathology in resected areas of FDG PET hypometabolism in pediatric epilepsy patients with focal cortical dysplasia type II
bioRxiv · · Preprint · Open access
Lam, von Ellenrieder + 7 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In 14 children with extra-temporal focal epilepsy and FCD type II, pathology was found in 75% of FDG-PET epicentre specimens versus 62% at surrounding hypometabolic borders.
- Why it matters: FDG-PET hypometabolism often extends beyond MRI-visible FCD, but it is unclear whether surrounding hypometabolic tissue contains epileptogenic pathology.
- What they did: The study retrospectively analyzed 136 resection specimens from the lesion epicentre and FDG-PET hypometabolic borders, using Bayesian logistic mixed modeling to compare pathology rates by location.
- The result: fFCD IIa/b log-odds were higher in the epicentre (1.00; CI 0.32–1.77) and lower at borders (-1.25; CI -2.17 to -0.40), while DNO showed no significant location effect.
The findingWhy it mattersWhat they didThe result
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