Research area · week to 3 Oct 2026

Epilepsy research and treatment

Moving in medRxiv, bioRxiv, Frontiers in Genetics, Nature Medicine.

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A pathogenic AMPAR mutation disrupts hippocampal synapse maturation and homeostasis
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.26.701845
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Presynaptic GABABSignaling Enhances Synaptic Inhibition Without Mitigating Persistent Dentate Gyrus Hyperexcitability After Status Epilepticus
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752988
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Epileptic discharges are classified as generalized paroxysmal fast activity with low expert agreement: findings from an international survey
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.18.26362075
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An AI-Assisted Study on EEG Spectral Power Gradients in Children with Monogenic Epilepsy
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.17.26363339
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Sleep fragmentation drives local, network-specific epileptic activity in human epilepsy
bioRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.11.30.691386
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Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma.
Nature Medicine · 17 Sept 2026 · Journal Article
Levetiracetam extends survival in children with diffuse midline glioma by targeting GABAergic synapses, but not in other glioma subtypes.
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https://jclub.com.au/a/42754728
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Interpretable Machine Learning Identifies an Emergent Absence Seizure Mechanism
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.23.678032
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Clinical and genomic characterization of corpus callosum abnormalities (CCA) in 107 Tunisian patients using a stepwise diagnostic approach.
Frontiers in Genetics · 14 Sept 2026 · Journal Article
Genomic abnormalities were identified in 10.3% of 107 Tunisian patients with corpus callosum abnormalities, highlighting the role of pathogenic CNVs in these disorders.
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https://jclub.com.au/a/42807679
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Fast-ripples are emergent properties of neuronal networks
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.15.706005
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Resting-state EEG network markers differentiate people with epilepsy and functional seizures
medRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.14.26350505
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Integrating rare and common variation in epilepsy genetics: from genetic architecture to penetrance and clinical expressivity.
Frontiers in Genetics · 24 Aug 2026 · Review
Integrating rare and common genetic variants reveals shared pathways influencing epilepsy severity and penetrance beyond traditional models.
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https://jclub.com.au/a/42703615
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Prevalence of malformations of cortical development in patients with suspected epilepsy based on a clinical MRI dataset
medRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.19.26360591
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Investigating the Influence of Anti-Seizure Medications on Aperiodic EEG Activity
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.02.686141
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NeuroMorph: A Unified Morphological Reference Space for Cross-Disease Brain Profiling
medRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.13.26359403
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Improved visualization and segmentation of the choroid plexus using double inversion recovery MRI
medRxiv · 16 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.13.26360360
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Topographic-prognostic gradients of cortical hypometabolism in temporal lobe epilepsy
medRxiv · 14 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.13.26360391
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Causal Network Mapping of sEEG Identifies Compact Epileptogenic Targets Concordant with Seizure Freedom: A Multicenter Study of 97 Patients
medRxiv · 5 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.21.26353792
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