Pioneer transcription factor ETS1 primes histone activation and drives 3D genome reorganization during osteoblast differentiation, with B-to-A chromatin shifts pre-marked in pre-osteoblasts.
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Bone Metabolism and Diseases
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IFN-γ-driven inflammation causes long-term bone marrow niche dysfunction after doxorubicin chemotherapy, impairing hematopoietic and skeletal health.
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Immunosuppressive tumor microenvironment remodeling in osteosarcoma increases pathological fracture risk by disrupting bone metabolism, with a significant impact on prognosis.
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