Sensing the skeleton: sensorineural regulation in bone.

Bone is a densely innervated sensory organ, with NGF–TrkA signalling coordinating somatosensory nerve growth and survival during skeletal development and repair.

• Why it matters: The field of skeletal neuroscience challenges the idea of bone as inert scaffold by addressing how nerves integrate mechanical, immune, and metabolic cues.
• What they did: The review synthesizes evidence using whole-tissue clearing, genetic tracing, and single-cell transcriptomics to map osteo-neural interactions with molecular detail.
• The result: It links NGF–TrkA pathways to pathological nerve sprouting, skeletal pain, and disease progression across osteoarthritis, heterotopic ossification, and bone malignancies, guiding future precision medicine work.

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