CORONAVIRUS INFECTION ACCELERATES EXPERIMENTAL OSTEOPOROSIS THROUGH THE ACTIVATION OF OSTEOCLASTS

MHV-A59 infection accelerates bone resorption in ovariectomy-induced osteoporosis in C57BL/6 mice, increasing osteoclast differentiation and activity at 5 dpi.

• Why it matters: Coronavirus infection is linked to systemic inflammation and extrapulmonary sequelae, but its effects on hosts with pre-existing osteoporosis are unclear.
• What they did: Female C57BL/6 mice underwent ovariectomy or sham surgery, then received intranasal MHV-A59 14 days later; femur remodeling was tracked by histopathology, micro-computed tomography, and biochemical assays through acute and chronic phases.
• The result: In OVX mice, infection accelerated bone loss during the acute phase (5 dpi), and in vitro MHV-A59 boosted osteoclast-associated markers and inflammatory mediators more strongly in OVX-derived cells.

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