The bile acid receptor TGR5 is a modulator of the bone marrow microenvironment

TGR5 deficiency in young male mice reduces bone marrow adipose tissue (BMAT) and is linked to accumulation of BM adipocyte progenitors, indicating impaired progenitor differentiation.

• Why it matters: The gut–bone marrow signaling axis is increasingly recognized, but TGR5’s specific contribution to the bone marrow niche—especially how it shapes adiposity—remains unclear.
• What they did: The study assessed TGR5 expression across hematopoietic populations and compared Tgr5-/- versus wild-type mice, testing steady-state hematopoiesis, short-term reconstitution, and BM niche changes across sex, obesity, and aging.
• The result: While steady-state hematopoiesis was unchanged, TGR5 deletion altered the microenvironment: BMAT expansion during obesity and aging was blunted in males, with reduced myeloid-lymphoid progenitor ratios.

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