Research area · week to 3 Oct 2026

Wnt/β-catenin signaling in development and cancer

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Latest in Wnt/β-catenin signaling in development and cancer

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Identification of Transcriptional Hippo Response Signature Connecting Inflammatory Bowel Disease and Colorectal Cancer Progression
medRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.26363887
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Density-Dependent Rearrangement of Desmoplakin in Epithelial Junctions: Insights from Expansion Microscopy
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721849
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Jag2 patterns early differentiation in the epidermal stem cell layer
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.28.708758
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Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis.
eLife · 8 Sept 2026 · Journal Article
SLAP suppresses EPHB2-SFK signaling, preventing excessive colonic epithelial proliferation and tumor development, highlighting its role as a tumor suppressor in the colon.
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https://jclub.com.au/a/42709470
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β-catenin controls Afadin cortical recruitment to regulate planar epithelial cell division
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.23.684278
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Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.
Cell · 3 Sept 2026 · Journal Article
A four-dimensional molecular map of hair follicle organogenesis reveals dynamic developmental processes in neonatal mouse skin.
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https://jclub.com.au/a/42385701
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Glycolytic suppression of cell adhesion promotes thyroid morphogenesis in response to nutrition.
EMBO Reports · 1 Sept 2026 · Journal Article
Glycolytic activity suppresses cell adhesion, promoting thyroid morphogenesis in Xenopus tadpoles, with a 50% increase in follicle formation under glycolytic conditions.
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https://jclub.com.au/a/42477468
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Zasp52's differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc.
eLife · 27 Aug 2026 · Journal Article
Zasp52's intrinsically disordered region is essential for thin filament stability at the Z-disc in Drosophila muscle, with deletion causing flightlessness and structural defects.
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https://jclub.com.au/a/42657781
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Cell cycle-coupled CK1δ turnover, autoinhibition, and activity
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.18.712569
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Polar growth factor PgfA regulates polar peptidoglycan synthesis as well as mycolate synthesis in Mycobacterium smegmatis.
Journal of bacteriology · 20 Aug 2026 · Journal Article
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https://jclub.com.au/a/42447029
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WNT-Driven Immune Evasion Promotes Malignant Transformation of BRAF-Mutant Colorectal Cancer.
Gastroenterology · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42612882
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Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.
Developmental Cell · 12 Aug 2026 · Journal Article
Tissue tension enables β-catenin phosphorylation to promote mesoderm formation in human embryonic stem cells, with 50% reduction in Brachyury (T) expression when disrupted.
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https://jclub.com.au/a/42442364
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Clinical, in vitro, and in vivo evidence of WAPL as a cohesinopathy-associated gene and phenotypic driver of 10q22.3q23.2 genomic disorder.
The American Journal of Human Genetics · 6 Aug 2026 · Journal Article
WAPL deficiency causes a developmental disorder with phenotypes linked to 10q22.3q23.2 deletions, establishing WAPL as a key driver gene in this region.
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https://jclub.com.au/a/42431198
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