Diet-Induced Obesity Exacerbates Helicobacter pylori-Associated Precancerous Phenotypes

High-fat diet (60% kilocalories from fat) increases Hp-associated inflammation and cancer-linked gene expression in C57BL/6 mice, especially at the glandular–forestomach junction.

• Why it matters: Obesity is linked to higher gastric cancer risk, but how diet-driven obesity interacts with Helicobacter pylori infection to shape precancerous disease is unclear.
• What they did: C57BL/6 and tamoxifen-inducible KRAS+ mice were fed high-fat (60%) or matched control (10%) diets, then infected with Hp or mock-infected; gastric pathology and gene expression were assessed.
• The result: In Hp-infected C57BL/6 mice, high-fat diet increased inflammation and elevated Cldn7 and Reg3g, and in KRAS+ mice it further expanded pseudopyloric metaplasia and dysplasia.

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