Research area · week to 3 Oct 2026

Biochemical and Structural Characterization

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How proteins fold.
Nature Reviews Molecular Cell Biology · 1 Oct 2026 · Journal Article
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Function-preserving watermarking of AI-generated proteins.
Nature · 30 Sept 2026 · Journal Article
SynthIDBio enables function-preserving watermarking of AI-generated proteins with near-perfect detection accuracy, ensuring provenance in biological engineering.
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Computational design of metalloproteases
bioRxiv · 27 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.20.689622
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A portable N-terminal biphenyl motif in LL-37 enhances the activity of short human cathelicidin derivatives
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.22.655619
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Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases.
Nature Communications · 22 Sept 2026 · Journal Article
Generative AI-designed thiolation domains enable up to threefold increased yields in reprogrammed non-ribosomal peptide synthetases.
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De novo design of cysteine proteases
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.21.689808
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Ubiquitin-Derived Diglycine Remnants as Chemical Handles for Chemoenzymatic Proteomics
bioRxiv · 20 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.29.735432
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The Rossmann2x2 Fold Attains its Native Structure Via a Defined Pathway of Sequential and Cooperative Folding Units
bioRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.21.726993
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Combinatorial deep mutational scanning uncovers protein superbinders and molecular determinants of epistasis.
Molecular Cell · 17 Sept 2026 · Journal Article
Combinatorial deep mutational scanning reveals epistatic superbinders that bind 3- to 5-fold tighter than existing PIN1 WW-domain binders.
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Beyond the promoter: the case for intein-mediated protein-level control in plant biotechnology.
Journal of Experimental Botany · 16 Sept 2026 · Journal Article
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https://jclub.com.au/a/42236285
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Targeted ortholog search in unannotated genome assemblies with fDOG-Assembly
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.19.677253
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De Novo Design of Miniprotein Inhibitors of Bacterial Adhesins
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.18.670751
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Serratia plymuthica.
Trends in Microbiology · 15 Sept 2026 · Journal Article
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From Attraction to Repulsion: Omicron-Driven Rewiring of Nanobody Interfaces on the SARS-CoV-2 RBD
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.18.665531
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A geometry-over-coevolution principle governs protein complex assembly in AlphaFold
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.03.716280
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A rugged binding landscape unifies static and dynamic paradigms in protein-protein interactions
bioRxiv · 4 Sept 2026 · Preprint
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High-Throughput Screening Identifies Small-Molecule Inhibitors of the Tau-LRP1 Interaction
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.24.733881
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Macrocyclization of native peptides through (thio)urea crosslinking of two amines.
Nature Communications · 2 Sept 2026 · Journal Article
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https://jclub.com.au/a/42823430
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The first OpenBind release: An open experimental structure-affinity dataset and benchmark for structure-based AI
bioRxiv · 1 Sept 2026 · Preprint
OpenBind's first release provides the largest single-target experimental structure-affinity dataset with 925 binding events for enteroviral 2A protease, advancing structure-based AI.
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https://jclub.com.au/a/10.64898/2026.08.27.747600
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Author Correction: Folding-mediated secretion of pure bispecific antibodies.
Nature Biotechnology · 1 Sept 2026 · Published Erratum
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https://jclub.com.au/a/41152627
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Substrate-dependent crosslinking by the cytochrome P450 from aminopyruvatide biosynthesis
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.07.723658
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Proteins feel the PINCH.
Nature Chemical Biology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/41644847
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Disulfide-bond-driven neck-ring-like conformation mediates SCREW recognition in plant immunity.
Nature Plants · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42754653
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A PLUM Job: Peptide modeLs for Understanding and engineering antiMicrobial therapeutics
bioRxiv · 20 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.21.707214
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PepXPro: a framework for curating, generating, and optimizing structure-affinity protein-peptide datasets
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.09.743757
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Pandoomain, a scalable pipeline for genomic and protein domain context analysis, reveals widespread PT-TG domain architectural diversity and novel polymorphic toxins.
mSystems · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42530337
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A contextualised protein language model reveals the functional syntax of bacterial evolution
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.20.665723
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Uncovering the mechanism of action of a historical antimicrobial against S. aureus and A. baumannii
bioRxiv · 11 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.02.703249
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Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins
bioRxiv · 10 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.07.716910
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