Multi-omics and AI integration reveal complex cancer microbiome patterns, advancing understanding and potential clinical applications.
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Cancer Research and Treatments
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Targeting cystine addiction reduces lung metastasis in MYC-driven breast cancer by exploiting a unique metabolic vulnerability.
Obesity and aging increase tissue-resident Akkermansia muciniphila in breast tissue by up to 50%, promoting oxidative stress and elevating postmenopausal breast cancer risk.
- Open access
Metastasis promotes tumor immunogenicity by producing migrasomes that deliver antigens and activate immune responses, reducing metastatic growth.
- Open access
Innovative delivery systems and formulations are key to advancing mRNA therapeutics 2.0, enabling repeated administration and targeted organ delivery beyond the liver.
Engineering Corynebacterium glutamicum and Escherichia coli has achieved record L-arginine titers up to 92.5 g/L, advancing microbial production capabilities for industrial use.
- 2 cites
Re-examining the temperate phage life cycle reveals complex interactions beyond traditional models, emphasizing the integration of properties previously considered separate.
Microbial systems have been engineered to significantly enhance the biosynthesis of SAM and its derivatives, enabling sustainable production of high-value compounds.
- 1 cites
Intravenous VCN-01 combined with gemcitabine and nab-paclitaxel improves overall survival in metastatic pancreatic ductal adenocarcinoma, meeting primary efficacy endpoints in the FAS population.
An iron-dependent methionine redox pathway controls adipose browning and cachexia, with MsrA deletion reducing cachexia and extending survival in mouse models.
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- 1 cites
Engineered OMV vaccine with nano-encapsulation prevents T cell exhaustion and reduces bacterial burden in chronic bacterial infections.
- Open access
Tumor-associated macrophages (TAMs) are the main nonmalignant cells accumulating albumin in tumors, with FcRn-mediated uptake crucial for their maturation and immunotherapy response.
- Open access
Multi-omics and AI integration reveal complex cancer microbiome patterns, advancing understanding and potential clinical applications.
- 1 opens in JClub
- Open access
Prophage-encoding engineered bacteria produce high levels of lytic phage, preventing Salmonella enterica Typhimurium infection and improving survival in mice.
- Open access
Extrachromosomal DNA and plasmids share key evolutionary functions, enabling rapid adaptation across bacteria and cancer cells, with ecDNA exhibiting similar dynamics to plasmids.
Macrophages transfer intact cancer cell surface proteins to their surface during live-cell uptake, significantly altering their proteome without transcriptional changes.
- Open access
- 1 cites
An optimized E. coli cell-free protein synthesis system reduces reaction components from 35 to 7, boosting efficiency and simplifying preparation for diverse applications.
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