Metastasis enables immunogenicity through migrasome-mediated antigen release.

Metastasis promotes tumor immunogenicity by producing migrasomes that deliver antigens and activate immune responses, reducing metastatic growth.

• Why it matters: Understanding how metastasis influences immune activation is crucial for developing therapies that harness the immune system to combat cancer spread.
• What they did: The study examined circulating tumor cells during vascular migration, revealing that they produce migrasomes rich in tumor antigens, which are captured by immune cells for cross-presentation.
• The result: Enhancing migrasome formation boosts immune responses against metastases, while inhibiting it worsens spread, positioning migrasomes as a key platform for endogenous tumor antigen delivery.