Recent advances in microbial production of S-adenosyl-L-methionine and its high-value derivatives.

Microbial systems have been engineered to significantly enhance the biosynthesis of SAM and its derivatives, enabling sustainable production of high-value compounds.

• Why it matters: Current industrial production relies on chemical synthesis, which poses environmental and sustainability concerns, highlighting the need for greener biomanufacturing methods.
• What they did: Recent advances in systems metabolic engineering and synthetic biology have been used to develop microbial platforms, focusing on improving SAM biosynthesis, utilization, and recycling, with particular emphasis on derivatives like ferulic acid, ergothioneine, and spermidine.
• The result: These strategies have advanced the microbial production of SAM-dependent compounds, paving the way for more sustainable and efficient manufacturing processes with broad applications in life sciences.