bioRxiv · 1 Oct 2026 · Preprint · Open access

Cumate-inducible models of MYC-driven neuroblastoma identify mitoribosomal synthetic lethality as a precision oncology vulnerability in MYC(N)-amplified tumors

Kubistova, Horak + 6 more

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The ITCC-P4 PDX Platform Enables Preclinical Testing of Pediatric Cancers.
Cancer Research · 2 Oct 2026 · Journal Article
The ITCC-P4 platform developed 353 pediatric cancer PDX models, enabling preclinical testing and biomarker discovery for high-risk solid tumors.
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https://jclub.com.au/a/42430560
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From Tissue Specificity to Systemic Cues: Shaping MYC-Driven Tumor Metabolism.
Cancer Research · 2 Oct 2026 · Review
MYC drives tissue-specific and systemic metabolic reprogramming in tumors, creating context-dependent vulnerabilities that can be targeted for therapy.
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https://jclub.com.au/a/42446901
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ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.02.671886
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