MYC drives tissue-specific and systemic metabolic reprogramming in tumors, creating context-dependent vulnerabilities that can be targeted for therapy.
Neuroblastoma Research and Treatments
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The ITCC-P4 platform developed 353 pediatric cancer PDX models, enabling preclinical testing and biomarker discovery for high-risk solid tumors.
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A pediatric patient-derived xenograft (PDX) program created 388 models across 40+ diagnoses, including ultra-rare tumors, enabling detailed cancer biology and therapy studies.
Loss of LDHA in breast cancer cells disrupts R-loop homeostasis, causing increased R-loop accumulation and DNA damage, with 199 peaks rising and 81 decreasing.
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CpG island hypermethylation and WNT/AP-1 activation define a high-risk subgroup with poor prognosis in pediatric adrenocortical carcinoma.
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DYP688, an antibody-drug conjugate targeting PMEL with a Gq/11 inhibitor payload, shows promising activity in GNAQ/GNA11-mutant melanomas with a 19.7% response rate.
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Talquetamab combined with daratumumab and pomalidomide significantly prolongs progression-free survival in relapsed or refractory multiple myeloma, with 24-month estimates over 81%.
Nuclear localization of MAP1B influences neural stem cell fate and is linked to neurodevelopmental disease, with 20% of cytoskeletal proteins found in the nucleus.
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