Gut-specific knock-down of enteroendocrine hormones AstC and Tk reduces fat storage exclusively in female Drosophila, highlighting sex-biased hormonal regulation.
- Open access
Invertebrate Immune Response Mechanisms
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Latest in Invertebrate Immune Response Mechanisms
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Cell traversal by Plasmodium sporozoites triggers innate immune responses essential for protective T cell activation, with 100% dependence on cell wounding signals.
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Active migration of Plasmodium sporozoites through host cells is essential for achieving sterilizing T cell-mediated immunity after vaccination, regardless of intrahepatic development.
- Open access
- 1 cites
Liver metabolic reprogramming and Th2/1 cell accumulation during H. bakeri infection sustain long-term anti-helminth immunity, with 14-day infection activating immune pathways.
Environmental temperature drives subspecies-level competition among Lactiplantibacillus plantarum clades in Drosophila simulans microbiomes, revealing functional diversification.
- Open access
Arginine kinase 1 is essential for Drosophila flight muscle development, supporting energy homeostasis and sarcomere maturation with a critical role in muscle growth.
- Open access
WNV infection induces durable neutralizing antibodies with a half-life of up to 472 days, but cross-reactivity against divergent lineages varies significantly among individuals.
- Open access
AP2-HS regulates environmental induction of sexual conversion in Plasmodium falciparum, involving a feedback loop that controls gdv1 expression and gametocyte formation.
Loss of cGAS in killifish reduces age-related cellular senescence and transcriptional aging signatures but does not extend lifespan.
- Open access
Exclusion of aPKC from the apical cortex in enteroblasts prevents overproliferation of intestinal stem cells in Drosophila midgut, maintaining tissue homeostasis.
Inhibition of Rag GTPases and mTORC1 in enterocytes increases intestinal stem cell activity via distinct pathways, with Rag GTPases affecting Mitf and mTORC1 acting independently.
The structure of the Plasmodium falciparum moving junction reveals a sailboat-shaped complex that actively remodels host red blood cell membranes during invasion.
TIF1γ is essential for maintaining regulatory T cell stability by restraining β-catenin signaling, preventing inflammatory reprogramming during immune challenges.
Draper-Src-Shark signalling in Drosophila intestinal stem cells detects tissue damage and drives proliferation, essential for midgut regeneration.
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