α-Synuclein reduces triglyceride levels and disrupts lipid droplet and mitochondrial structure, linking lipid metabolism to neurodegenerative toxicity in C. elegans.
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Sirtuins and Resveratrol in Medicine
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Zonated cholesterol sensing by SIRT2 initiates MASLD-related hepatocellular carcinoma, with SIRT2 overexpression in zone 1 causing tumors in mice and humans.
Proteome-wide profiling reveals 17,102 lysine β-hydroxybutyrylation sites in Reynoutria japonica, linking Kbhb to plant stress response and metabolism regulation.
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Multiple distinct gene expression programs define at least three different longevity strategies in Caenorhabditis elegans, with some pathways modulating genes in opposing directions.
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