Whole-blood NAD levels track cardiovascular disease but not chronological age.

Whole-blood NAD levels in 1,068 adults do not decline with age in healthy individuals, but are reduced in cardiovascular disease and hypertension.

• Why it matters: It remains unclear whether whole-blood NAD changes reflect normal ageing or instead track specific human diseases.
• What they did: The study performed 1,340 whole-blood NAD measurements across adults, comparing levels by age and by chronic disease status, including cardiovascular disease and hypertension.
• The result: NAD levels are stable with age in healthy people (stable in males, increasing in females) yet are lower in cardiovascular disease and hypertension, suggesting NAD tracks these conditions rather than chronological age.

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