A human iPSC-derived spheroid model reveals that remyelinated axons have thinner myelin sheaths after injury, advancing understanding of human myelin repair mechanisms.
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Nerve injury and regeneration
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A new protocol enables reliable culture and transcriptome profiling of human Schwann cells from small sural nerve biopsies, facilitating PNP research.
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Self-organizing human dual neural organoids (hPCOs) reveal Wnt signaling's bidirectional role in central and peripheral nervous system development, modeling key disease defects.
Chronic fluoxetine treatment reactivates juvenile-like plasticity in the dentate gyrus, promoting synaptic rejuvenation and reducing fear generalization in mood disorder models.
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Cortical α-synuclein pathology causes neuronal hypoactivity and circuit changes without impairing visuoperceptual function in a mouse model of early Lewy body dementia.
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