The abstract is read at the publisher; the summary is JClub's.
In mouse spinal cord, 47–75% of cells show increased ERK phosphorylation at peak after BDNF, but sensitivity depends on sustained surface TrkB reduction rather than receptor stoichiometry alone.
- Why it matters: BDNF signaling is pleiotropic, yet it is unclear how single cells in different spinal cord lineages and maturation states decode the same cue into distinct responses.
- What they did: Using highly multiplexed single-cell mass cytometry, the study measured 19 signaling markers and 18 cell ID markers to build a temporal atlas across two control conditions.
- The result: TrkB/p75NTR receptor stoichiometry predicts response potential, while sustained reduction of surface TrkB predicts BDNF sensitivity; identical receptor profiles still produce different signaling, implying cell identity sets interpretation.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.