Intestinal epithelial cells presenting cytosol-delivered bacterial antigens program robust barrier immune memory, with significantly enhanced responses compared to bacterial retention.
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Immune responses and vaccinations
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NLRP3 inflammasome integrates innate immune signaling and cell death pathways, coordinating inflammatory responses and pyroptosis during infections and inflammation.
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Engineered OMV vaccine with nano-encapsulation prevents T cell exhaustion and reduces bacterial burden in chronic bacterial infections.
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ConvexGating automatically infers interpretable gating strategies with high accuracy for cell sorting from single-cell cytometry data, including unknown populations, enabling practical implementation.
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C3-C3aR signaling enhances trained immunity in alveolar macrophages, with C3 deficiency impairing cytokine production and metabolic activity in mice.
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Impaired bone marrow myelopoiesis driven by IFN-I response limits monocyte brain homing and accelerates Alzheimer's disease progression in mouse models and patients.
Incorporating spatially adjusted protein summaries improves survival prediction in spatial proteomics, achieving higher accuracy than traditional methods in breast cancer data.
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Fusobacterium nucleatum promotes exosomal MANCR secretion from colorectal cancer cells, increasing PD-L1 expression in macrophages and impairing antitumor immunity.
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