Research area · week to 3 Oct 2026

Molecular Biology Techniques and Applications

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Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.11.669689
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Technological advances in extrachromosomal circular DNA detection.
Biotechnology advances · 1 Oct 2026 · Review
Advances in sequencing and genome editing have significantly improved detection and understanding of extrachromosomal circular DNA (eccDNA), revealing new insights into genome organization.
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https://jclub.com.au/a/42349764
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Defining transcriptomic niches in human fibrotic lung with multi-sample spatial transcriptomics analysis using the MAPLE algorithm
bioRxiv · 1 Oct 2026 · Preprint
Multi-sample spatial transcriptomics reveals distinct regional fibrotic programs and cellular niches in human IPF, with 10X Xenium validation confirming key findings.
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https://jclub.com.au/a/10.1101/2022.02.28.482296
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Experimentally Defined Tm-Guided Exon Exon Junction Primer Design Enables Specific Discrimination of Highly Similar RNA Variants
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.02.716213
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Translesion synthesis polymerase kappa is recruited to ribosomal DNA to maintain rRNA transcription
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2022.10.27.513845
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Spatiotemporal trajectories of formaldehyde fixation effects on quantitative MRI in postmortem human brains
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.05.723107
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Recovery of genomic and transcriptomic profiles from decades-old FFPE brain tissues
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.20.719637
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Serum, cell-free, HPV-human DNA junction detection and HPV typing for predicting and monitoring cervical cancer recurrence.
eLife · 9 Sept 2026 · Journal Article
Detection of tumor-specific HPV-human DNA junctions in serum predicts cervical cancer recurrence with higher accuracy than HPV type alone.
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https://jclub.com.au/a/42713958
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The Indian Cancer Genome Atlas:A Multi-Omics Resource for Advancing Cancer Research
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.25.645286
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Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.14.675889
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Hybridization chain reaction variants with enhanced sensitivity for detecting challenging mRNA targets
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.09.675218
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Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors.
Nature Biotechnology · 1 Sept 2026 · Journal Article
De novo mitotic errors, including multipolar spindles and lagging chromosomes, occur frequently in late-stage preimplantation human embryos, with most lagging chromosomes passively inherited.
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https://jclub.com.au/a/41131150
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Confounders of lncRNA screens: sources, consequences and possible solutions.
Nature Methods · 31 Aug 2026 · Journal Article
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https://jclub.com.au/a/42675119
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Decoding Radiation-Induced Transcriptomic Signatures of Human Leukocytes using Long-Read RNA-Seq: Clinical and Biodosimetric Implications
bioRxiv · 29 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.04.703787
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Analysis of RNA processing directly from spatial transcriptomics data reveals previously unknown regulation
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.03.13.532412
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MethylHDA: One-pot helicase-dependent amplification with concurrent DNMT1-mediated maintenance of DNA methylation
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.05.709983
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Systematic assessment of transcriptomic and phenotypic biological profiling for mechanism-based hazard assessment using target-annotated reference chemicals in renal proximal tubular epithelial cells
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.08.743660
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RobustCell: A Model Attack-Defense Framework for Robust Transcriptomic Data Analysis
bioRxiv · 13 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.19.624294
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Myelin-Free Nuclei Isolation from Mouse Hippocampus and Cerebellum for snRNA-Seq with Benchtop Gradient Centrifugation
bioRxiv · 9 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.03.716374
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A simple method for analyzing competitive growth of multiple cell types in xenograft tumors
bioRxiv · 6 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.23.701386
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