Cholesterol and Lipid Metabolism

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Papers in 60 days: 11

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A signal to boost cholesterol.
Nature Cell Biology · 9 Oct 2026 · Journal Article
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PDE5A Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking through a Noncanonical cGMP-Dependent Pathway.
Cancer Research · 2 Oct 2026 · Journal Article
PDE5A inhibitors, including sildenafil, induce lysosomal cholesterol accumulation and reduce metastasis in cancer models by disrupting NPC1-mediated cholesterol trafficking.
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LIPC-E97G Gain-of-function variant potentiates the hypocholesterolemic and anti-atherogenic effects of evinacumab in Ldlr-/- mice
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.28.754893
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VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease.
EMBO Reports · 22 Sept 2026 · Journal Article
VGLL4 promotes MAFLD progression by enhancing PDK4 transcription, with hepatocyte-specific overexpression inducing steatosis and knockout protecting mice from metabolic dysfunction.
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Zonated cholesterol sensing by SIRT2 drives MASLD-HCC.
Cell Metabolism · 17 Sept 2026 · Journal Article
Zonated cholesterol sensing by SIRT2 initiates MASLD-related hepatocellular carcinoma, with SIRT2 overexpression in zone 1 causing tumors in mice and humans.
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Fatty acid metabolism controls plasma membrane cholesterol accessibility via ATGL-dependent phospholipid remodeling
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.21.671640
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Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity.
Nature Cancer · 1 Sept 2026 · Journal Article
Targeting PID1 in tumor-associated macrophages produces oxysterols that reprogram macrophages toward an antitumor phenotype, enhancing immune responses in multiple cancers.
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Familial Hypercholesterolemia.
JAMA · 25 Aug 2026 · Journal Article
Familial hypercholesterolemia affects both homozygous and heterozygous individuals, requiring tailored assessment, diagnosis, and management strategies.
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Sustained 1,25(OH)2D elevation promotes biphasic cholesterol elimination through bile acid and sterol pathways
bioRxiv · 20 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.11.724189
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Bisphenol A-mediated GPER1/PPARγ/ACC/FAS signaling induces de novo lipogenesis and lipid accumulation in luminal and triple-negative breast cancer cells to regulate epithelial-mesenchymal plasticity.
Environmental pollution · 14 Aug 2026 · Journal Article
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Alcohol-Induced Metabolic Stress Sensed by m6A-Modified ChREBP Drives Immune Evasion in Esophageal Carcinogenesis.
Cancer Research · 14 Aug 2026 · Journal Article
Alcohol-sensitive ChREBP epitranscriptomic modification promotes immune evasion and drives esophageal squamous cell carcinoma in over 200,000 individuals.
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