Silencing SsUBA52 in Sclerotinia sclerotiorum increases pathogenicity and alters development, reducing sclerotia but boosting infection capabilities by 50%.
Heat shock proteins research
Moving in bioRxiv, Plant Physiology and Biochemistry, EMBO Reports, Journal of Experimental Botany, Applied and environmental microbiology, Cancer Research, Cell, EMBO Journal.
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FBXL21 controls diurnal proteostasis in skeletal muscle by degrading DNAJB6 and its client proteins, with mutations conferring resistance and disrupting protein balance.
- Open access
Cancer cells inactivate the mitochondrial tumor suppressor LACTB through enhanced autoproteolysis mediated by MRPS34 in breast cancers.
- Open access
Restricting larval protein intake reduces Lsp2 levels, decreases ribosomal proteins, and extends adult lifespan in Drosophila by up to a significant margin.
- Open access
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Cytoplasmic AtHsp18.5 enhances drought and lead tolerance in Arabidopsis thaliana by acting as a molecular chaperone and regulating stress-responsive genes.
- Open access
RsHSFA3 enhances heat tolerance in Rhododendron simsii by activating heat shock proteins and improving ROS scavenging capacity.
- Open access
Chloroplasts utilize a RAF3/6 kinase module to coordinate energy production and stress responses during cold stress, with RAF6 variation linked to cold adaptation.
NtEPF3 and NtEPFL6 peptides enhance drought tolerance in tobacco by regulating stomatal function and kinase signaling pathways.
- Open access
FAF1 and FAF2 significantly boost p97-UFD1-NPL4 complex activity, increasing substrate unfolding efficiency by engaging key cofactors and conserved activation motifs.
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Genomics and biotechnology advances have identified key genetic loci and mechanisms that enable wheat to tolerate heat stress, accelerating breeding for climate resilience.
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A novel ~25 kDa isoform of PANX1, expressed in mouse melanoma cells, interacts with full-length PANX1 and is prevalent in cancer progression.
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ETS1 drives a hybrid EMT program that promotes metastasis and immune evasion in upper aerodigestive squamous cell carcinoma, with high expression linked to poor survival.
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