Research area · week to 3 Oct 2026

Ion Transport and Channel Regulation

Moving in bioRxiv, Nature Communications, eLife, Communications Biology, Frontiers in Genetics, Nature Plants.

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PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons.
eLife · 29 Sept 2026 · Journal Article
PKD2L1 channels in cerebrospinal fluid-contacting neurons act as dual-mode pH sensors, with high sensitivity around physiological pH levels.
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https://jclub.com.au/a/42809452
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Aquaporin-9 and aquaporin-10 but not aquaporin-3 confer susceptibility to dimethylarsinic acid genotoxicity in human cells
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752519
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Spatial proteomics identifies FXYD6 as a dual-site protein of neuromuscular junction in the diaphragm.
Communications Biology · 18 Sept 2026 · Journal Article
Spatial proteomics reveals FXYD6 as a dual-site protein at the neuromuscular junction in the diaphragm, with significant enrichment in type IIa fibers.
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https://jclub.com.au/a/42760317
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Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions.
Nature Communications · 17 Sept 2026 · Journal Article
LRRC8A/D heteromeric channels are activated by cell swelling and modulated by sybodies, with a specific structure of four A and two D subunits revealing key conformational states.
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https://jclub.com.au/a/42754598
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WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.10.731153
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PRRT2 as an auxiliary regulator of Nav channel slow inactivation.
eLife · 11 Sept 2026 · Journal Article
PRRT2 enhances Nav channel slow inactivation and delays recovery, affecting neuronal excitability from zebrafish to humans.
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https://jclub.com.au/a/42725411
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SLC4A7/NBCn1 maintains intracellular pH to support mTORC1 activity and antibody-secreting cell differentiation.
Nature Communications · 11 Sept 2026 · Journal Article
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CD239 deficiency in distal tubules impairs cell polarity and increases susceptibility to renal injury
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.31.728029
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Genetic compensation in podocalyxin-like mutants during zebrafish liver development
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.07.647300
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Col-0 genetic divergence.
Nature Plants · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42711405
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Structural Insights into the Coupling Mechanism of Vectorial CO2 Uptake by DAB1
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.01.722082
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Expanding the genetic landscape of SLC4A1-linked hereditary spherocytosis: discovery of a novel TM9 variant using high-resolution genomic profiling analysis.
Frontiers in Genetics · 27 Aug 2026 · Journal Article
Seven SLC4A1 variants, including a novel p.Phe702Ser in TM9, were identified in Indian hereditary spherocytosis patients, expanding the mutation spectrum.
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https://jclub.com.au/a/42719912
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PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.24.671961
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Amiloride mitigates respiratory distress caused by WFDC2 deficiency via inhibiting the epithelial sodium channel.
Nature Communications · 12 Aug 2026 · Journal Article
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https://jclub.com.au/a/42717213
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Structure of NHE6 and its lipid-mediated interactions regulating endosomal pH.
Nature Communications · 11 Aug 2026 · Journal Article
Cryo-electron microscopy reveals NHE6 as a homodimer with lipid-dependent regulation, crucial for endosomal pH control, with structures at 2.2–3.3 Å resolution.
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https://jclub.com.au/a/42581050
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Impaired renal base excretion in secretin receptor knock-out mice during prolonged base-loading
bioRxiv · 7 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.05.709818
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