CDK2 inhibitors induce RB-independent tumor suppression in CDK4/6 inhibitor-resistant HR+/HER2- breast cancer, with disease stabilization observed in patients.
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Cancer-related Molecular Pathways
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Eighteen candidate TCDD-associated targets, including five hub genes, were identified in retinoblastoma, with CDK1 showing the strongest link to cell-cycle dysregulation.
- Open access
Chronic exposure to cigarette and waterpipe smoke extracts causes telomere shortening and increases telomerase activity, promoting cancer progression in lung, colon, and breast cancer cells.
- Open access
A novel CDC45 variant and a recurrent East Asian variant were identified in a Chinese MGORS7 patient, expanding the mutational spectrum of the disorder.
- Open access
Deletion of cFLIP in B cells prevents diffuse large B-cell lymphoma development in mice, highlighting its essential role in lymphoma pathogenesis.
- Open access
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ARISC-RAP80 recognizes and cleaves K63-linked polyubiquitin chains through a unique three-subunit interface, enabling precise DNA damage response regulation.
- Open access
Bi-allelic loss-of-function variants in CDK20 cause a severe ciliopathy with midline brain and facial anomalies in seven individuals from five families.
Chemically induced skin tumors mainly originate from Lgr6+ and Lrig1+ stem cells in the upper hair follicle, with fewer arising from other hair follicle populations.
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