Ethics in Clinical Research
Moving in medRxiv, BMJ, Frontiers in Genetics, JAMA, The Lancet Oncology, Blood, Cancer Research, eLife.
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Expanding cancer susceptibility testing to the general population requires careful evaluation of clinical and public health benefits, with evidence supporting its use mainly for well-established genes.
- 1 cites
Decentralized clinical trials can improve patient access and reduce costs but face significant logistical and regulatory challenges, as demonstrated in hematology research.
European Health Data Space and biobanking integration could create a trustworthy, federated health research infrastructure in Europe, but faces significant governance and technical challenges.
- Open access
Effective communication behaviors in clinical encounters can enhance trust and improve participation of underrepresented populations in biobanking, as shown by preliminary findings.
- Open access
Most clinical trials with shared individual participant data (IPD) produced secondary publications, with external investigators contributing nearly 18% of these, increasing over time.
- Open access
- 1 cites
Strengthening advocate-researcher partnerships can significantly improve cancer research outcomes and patient-centered care.
Most replication success metrics, except meta-analysis and Bayes factor, become liberal with increasing heterogeneity, limiting their reliability in animal-to-human translation assessment.
- Open access
Open sharing of individual patient data in BMJ trials increased from 0% to 58% after the 2024 policy change, surpassing rates in other major medical journals.
- Open access
- 4 cites
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