The Participant Engagement and Cancer Genome Sequencing Network to accelerate research in rare and understudied cancers.

The US National Cancer Institute’s PE-CGS Network integrates participant engagement, return of results, and paired tumor/germline sequencing to advance rare and understudied cancer genomics.

• Why it matters: Genomic research still has gaps in tumor profiling for rare cancers and for populations underrepresented in genomic studies, alongside limited integration of genomic, clinical, and epidemiologic data.
• What they did: PE-CGS includes five research centers plus a coordinating center and external advisory panel, using participant-centered engagement and collecting clinical and epidemiologic data with paired tumor/germline sequencing.
• The result: The network shows that engagement and comprehensive data collection can be combined in participant-centered cancer genomics research, aiming to accelerate studies in rare and understudied cancers.

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