Research area · week to 3 Oct 2026

DNA and Nucleic Acid Chemistry

Moving in bioRxiv, Nature Communications, Molecular therapy. Nucleic acids, Nature Chemical Biology, Nature Reviews Molecular Cell Biology, Cancer Research, Molecular Cell, Science.

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Latest in DNA and Nucleic Acid Chemistry

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HoT self-blinking probes for chromatin imaging.
Nature Reviews Molecular Cell Biology · 1 Oct 2026 · Journal Article
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Decoding the recoding.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
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Single-stranded telomeric repeats segregate into spatial compartments within ALT-associated PML bodies
bioRxiv · 30 Sept 2026 · Preprint
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De novo design of functional RNAs through higher-order interactions
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.26.754601
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Scaling of structural variability of ecDNA polymer condensates with copy number boosts and stabilises oncogene regulatory contacts
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754334
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VIPR RNA-guided DNA recognition by noncontiguous geometric triplex formation.
Science · 17 Sept 2026 · Journal Article
VIPR systems achieve precise DNA targeting through noncontiguous triplex formation, with 21 cryo-EM structures revealing the mechanism of target engagement.
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How to grow a filament: Lessons from the RAD51 paralogs toolbox.
Molecular Cell · 17 Sept 2026 · Comment
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Transcriptome-wide mapping reveals a non-canonical RNA-dependent mechanism of platinum cancer drugs
bioRxiv · 16 Sept 2026 · Preprint
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Small-molecule inhibitors block NorA efflux by conformational trapping.
Nature Chemical Biology · 16 Sept 2026 · Journal Article
IMP-2380 effectively inhibits the NorA efflux pump in Staphylococcus aureus, restoring antibiotic susceptibility with low-nanomolar potency and structural trapping of the transporter.
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Near-critical chromatin fluctuations facilitate long-range contacts in Drosophila chromosomes
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.20.660702
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PKProbDesign: RNA inverse folding including pseudoknots by optimizing thermodynamic folding probability
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.09.736945
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Determinants of centromeric nucleosome conformation
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.15.724335
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Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.
Cancer Research · 2 Sept 2026 · Journal Article
POLE exonuclease deficiency causes synthetic lethality in highly aneuploid cancer cells, revealing a potential targeted therapy approach.
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Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase.
Nature Communications · 2 Sept 2026 · Journal Article
E. coli RNA polymerase can efficiently transcribe an eight-letter genetic alphabet, including two orthogonal unnatural base pairs, with high fidelity and structural compatibility.
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Real-time single-molecule imaging in zebrafish embryos uncovers non-canonical translation
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.05.697684
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Elucidating structure-function relationships in the mammalian nucleolus.
Nature Reviews Molecular Cell Biology · 1 Sept 2026 · Review
High-resolution imaging reveals complex, dynamic architecture of mammalian nucleoli essential for ribosome biogenesis.
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Towards density-optimal DNA storage with practical bijective coding.
Nature Communications · 27 Aug 2026 · Journal Article
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Geometry of Braided DNA Dictates Supercoiling Partitioning
bioRxiv · 24 Aug 2026 · Preprint
DNA braid geometry influences supercoiling partitioning by modulating torsional resistance, with small separations enabling fork rotation and larger separations creating barriers.
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https://jclub.com.au/a/10.1101/2024.10.08.617221
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Multiplexed construction of defined DNA products from unpartitioned oligonucleotide pools
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.01.722326
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Morphology, Slow Dynamics, and Composition-Controlled Phase Behavior in a Minimal Model of Dps:DNA Co-Condensation
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.11.28.691232
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Dual recognition drives site-directed G-quadruplex stabilization: Oligonucleotide design in G4 ligand-oligonucleotide conjugates.
Molecular therapy. Nucleic acids · 14 Aug 2026 · Journal Article
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Dynamism and evolvability in nucleic acid enzymes.
Nature Communications · 14 Aug 2026 · Journal Article
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Safety and toxicity assessment of antisense oligonucleotides in brain-relevant human cellular models.
Molecular therapy. Nucleic acids · 13 Aug 2026 · Review
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Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling.
Molecular therapy. Nucleic acids · 12 Aug 2026 · Journal Article
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TDP-43 controls RNA structure through high affinity lattice interactions.
Nature Communications · 12 Aug 2026 · Journal Article
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A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage
bioRxiv · 11 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.09.723998
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Extensive binding of poorly characterized human transcription factors to genomic dark matter.
Nature Communications · 5 Aug 2026 · Journal Article
Nearly half of 166 poorly characterized human transcription factors bind extensively to genomic dark matter, revealing new insights into genome regulation.
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