Enhancing P450 enzyme components with greater degrees of freedom can significantly expand biocatalytic applications in pharmaceutical manufacturing.
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Pharmacogenetics and Drug Metabolism
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Simulation-guided clinical trial design enhances decision-making and accelerates drug development by optimizing complex adaptive strategies.
Noncanonical cytochrome P450 enzymes lacking the conserved cysteine are widespread, with 20 distinct families identified in diverse microbial genomes.
High-resolution GWAS of nearly 600,000 East Asians reveals 196 loci for type 2 diabetes, with 3 new loci and 74% shared causal signals across populations.
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Integrating targeted genetic approaches with genome-wide evidence enhances clinical pharmacogenetics in psychiatry, especially for pharmacokinetic and pharmacodynamic traits.
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