Research area · week to 3 Oct 2026

Antifungal resistance and susceptibility

Moving in Virulence.

Moved this week: 2

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Pathogenicity and virulence of Candida auris.
Virulence · 31 July 2026 · Review
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Latest in Antifungal resistance and susceptibility

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Mapping virulence-associated protein interaction networks reveals regulators of thermotolerance in Cryptococcus neoformans
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754343
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Safety, Feasibility, and Preliminary Clinical Findings of an Oral Polypore Fungi Combination with Mild-to-Moderate COVID-19: A Randomized, Placebo-Controlled Phase I Clinical Trial
medRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.01.26354267
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Defining the Candidozyma auris pan-genome and essentiality
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.12.724661
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Antigen-restricted Candida albicans Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation.
Immunity · 8 Sept 2026 · Journal Article
C. albicans-specific Th17 cells are shared across oral and gut mucosa, with significant enrichment in Crohn's disease, linking commensal fungi to intestinal inflammation.
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Candida albicans reprograms Staphylococcus aureus glycolytic metabolism to drive enhanced virulence.
Virulence · 4 Sept 2026 · Journal Article
Candida albicans reprograms Staphylococcus aureus glycolytic pathways, increasing its virulence by 2- to 3-fold in glucose-rich environments.
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Comparative genomic analysis reveals distinct population structure in Legionella anisa.
FEMS microbiology letters · 3 Sept 2026 · Journal Article
Genomic analysis uncovers three distinct, highly divergent populations of Legionella anisa, with a clonal lineage identified in a Canadian healthcare facility.
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https://jclub.com.au/a/42690043
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Emergence of human pathogenic fungi in a changing climate.
Nature Reviews Microbiology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42448915
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Molecular dynamics modeling of the Candida albicans membrane for the discovery of membrane-binding antifungal peptides.
Mycologia · 1 Sept 2026 · Journal Article
PinA and XYP1 peptides demonstrate strong, stable binding to Candida albicans membranes, effectively inhibiting fungal growth in vitro without harming human cells.
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https://jclub.com.au/a/42269144
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IL-1 family signalling drives mucosal defence against systemic Candida albicans infection.
Nature Microbiology · 1 Sept 2026 · Journal Article
IL-1 family signalling is essential for mucosal defense against systemic Candida albicans, preventing dissemination and mortality in neutropenic conditions.
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https://jclub.com.au/a/42557355
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The future of fungal diagnostics: What's next in laboratory testing for invasive fungal infection?
Medical Mycology · 29 Aug 2026 · Review
Advances in molecular techniques and point-of-care tests promise faster, more accurate diagnosis of invasive fungal infections, potentially saving lives and reducing resistance.
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https://jclub.com.au/a/42631730
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Machine learning-integrated multi-omics risk prediction for pulmonary fungal infection in COPD and lung cancer: a transcriptomic and immune profiling study.
Frontiers in Genetics · 28 Aug 2026 · Journal Article
Machine learning combined with multi-omics data predicts pulmonary fungal infection risk in COPD and lung cancer with an AUC of 0.988.
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https://jclub.com.au/a/42725278
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Protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in Cryptococcus neoformans
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.10.693573
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Insight into the role of Sho1 in high-hydrostatic pressure and oxidative stress adaptation of the hadal fungus Aspergillus sydowii DM1.
Applied and environmental microbiology · 19 Aug 2026 · Journal Article
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https://jclub.com.au/a/42461035
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A cornea-specific role for the Aspergillus fumigatus carbon catabolite repressor, CreA, in tissue penetration and infection establishment
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.13.744696
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Candida spp. suppress neutrophil reactive nitrogen species to evade killing.
mBio · 12 Aug 2026 · Journal Article
Candida spp. suppress neutrophil reactive nitrogen species below basal levels during infection, aiding fungal evasion and survival in host organisms.
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https://jclub.com.au/a/42405803
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Spatiotemporal compartmentalization of NADPH oxidase signaling coordinates cell fusion and predatory behavior in nematode-trapping fungi.
mBio · 12 Aug 2026 · Journal Article
Distinct NADPH oxidases in Arthrobotrys flagrans coordinate cell fusion and prey capture through spatially compartmentalized ROS signaling.
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https://jclub.com.au/a/42454936
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mGem: A perfect storm in the era of global warming-the convergence between thermotolerant fungi and altered immunity.
mBio · 12 Aug 2026 · Review
Global warming promotes thermotolerance in fungi and alters human immunity, increasing the risk of emerging fungal infections like Candida auris and Rhodosporidiobolus fluvialis.
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https://jclub.com.au/a/42383752
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Dipeptidyl peptidase IV contributes to the pathogenesis of Cryptococcus neoformans.
mBio · 12 Aug 2026 · Journal Article
Cryptococcus neoformans relies on surface-associated Dpp4 enzyme for virulence, with deletion reducing pathogenicity and delaying host mortality in animal models.
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https://jclub.com.au/a/42474189
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The transcription factor Ahr1 governs the recruitment of neutrophils to the brain and clearance of Candida albicans during CNS infection.
mBio · 12 Aug 2026 · Journal Article
Ahr1 transcription factor is essential for activating the NLRP3/IL-1β pathway, recruiting neutrophils, and clearing Candida albicans from the brain, with 100% dependence observed in vivo.
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https://jclub.com.au/a/42474181
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The genotoxic stress-inducible gene GEI1(Orf19.3109) is a repressor of virulence in Candida albicans.
Virulence · 11 Aug 2026 · Journal Article
GEI1 gene acts as a repressor of virulence in Candida albicans, with its deletion causing a 2- to 3-fold increase in extracellular protease secretion and hypervirulence.
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