The abstract is read at the publisher; the summary is JClub's.
Manogepix exposure of Candida auris strains B11103, B11221, and B11244 induces formation of viable yeast aggregates at 1× MIC (0.008–0.016 mg/L) up to 8× MIC (0.06–0.125 mg/L).
- Why it matters: Multidrug-resistant C. auris poses a major treatment challenge, and tolerance mechanisms linked to aggregate survival could undermine antifungal efficacy.
- What they did: Time-kill curves were measured on YPD agar and by flow cytometry using FSC/SSC, propidium iodide staining, and morphology, with confocal microscopy assessing aggregate structure, staining, and reversibility.
- The result: Aggregates retained largely intact morphology, showed limited PI-positive cells, and could grow on agar and dissociate after drug removal, implying manogepix may require concentrations well above MIC to prevent viable aggregate formation.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.