Poor glycemic control in diabetic patients significantly increases Candida infections, which reach 83.3% in those with HbA1c ≥8.0%, compared to dermatophyte infections in better-controlled patients.
Medical Mycology
Oxford University Press · Microbiology & Mycology · ISSN 1369-3786, 1460-2709
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Posttransplant Candida colonization and surgical complications significantly increase the risk of invasive Candida infections in solid organ transplant recipients, especially within the first year.
An outbreak of mucormycosis caused by Rhizomucor pusillus in a Brazilian HSCT unit resulted in four cases over ten months, with three patients surviving after early treatment.
Candidozyma auris candidemia causes 41% 28-day mortality in critically ill patients, with high resistance to fluconazole and significant impact from comorbidities and organ failure.
High-mortality outbreaks of rare and emerging molds in hospitals require a systematic approach for investigation and prevention, especially given their unique environmental niches and unknown incubation periods.
Heteroresistance to fluconazole was common among Cryptococcus isolates but not significantly linked to relapse within six months in neurocryptococcosis patients.
Whole-genome sequencing reveals that Trichophyton mentagrophytes genotype VII forms a highly clonal, distinct population causing sexually transmitted dermatophytosis.
A novel G982E mutation in MRR1 causes high-level fluconazole resistance and treatment failure in Candida parapsilosis.
Dematiaceous fungal keratitis accounts for 3.88% of fungal keratitis cases in North India, with Curvularia spp. being the most prevalent causative agent.
Forty-five percent of Ecuadorian field biologists show prior exposure to Histoplasma capsulatum, revealing significant occupational risk in endemic environments.
Elevated terbinafine and fluconazole MICs in Trichophyton mentagrophytes complex isolates are linked to specific molecular changes, including SQLE mutations and increased MDR2 expression.
Non-albicans Candida species, especially C. parapsilosis and C. tropicalis, exhibit higher virulence factors and antifungal resistance, correlating with increased mortality in bloodstream infections.
Severe COVID-19 patients in Brazil harbor diverse Aspergillus species with 100% showing non-wild-type phenotypes against posaconazole, indicating emerging antifungal resistance.
Anti-Aspergillus spp. IgG antibodies seroconvert in 70% of COVID-19-associated pulmonary aspergillosis patients, typically around 8 days after diagnosis in ICU settings.
Persistent candidemia occurs in 1 out of 3 cases and is linked to higher mortality and longer hospital stays in hospitalized patients.
Molecular identification revealed 90.4% of Microsporum canis complex isolates in Abu Dhabi, with 9.6% misidentified phenotypically, highlighting the importance of ITS sequencing.
Urinary Histoplasma antigen detection identified 23.1% of symptomatic PLWH with suspected disseminated histoplasmosis, with high agreement between EIA and LFA methods.
Seroprevalence of anti-Coccidioides IgG antibodies is 7.3% among residents in nine municipalities of Sonora, Mexico, indicating widespread exposure to Coccidioides spp. in an endemic region.
Posaconazole and surgery effectively manage Alternaria spp. infections in immunocompromised adults, with 52% of patients receiving oral therapy and 52% undergoing surgery.
Advances in molecular techniques and point-of-care tests promise faster, more accurate diagnosis of invasive fungal infections, potentially saving lives and reducing resistance.
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T. indotineae and T. mentagrophytes ITS genotype VII together account for 39.1% of T. mentagrophytes complex isolates in France, highlighting emerging public health concerns.
Candida bloodstream infection occurs in approximately 3% of LVAD patients and results in a 62.5% mortality rate, highlighting its severity in this population.
Oral wash PCR detects Pneumocystis jirovecii pneumonia with 97.2% specificity but only 61.5% sensitivity in non-HIV immunocompromised patients.
Entomophthoromycosis exhibits distinct epidemiological patterns, clinical forms, and a 10.93% overall mortality rate across 405 global cases from 2000 to 2023.
Short tandem repeat genotyping reveals a long-standing, highly transmissible clinical lineage of Pichia kudriavzevii across hospitals and countries, with 52 genotypes and multiple clusters.
A nine-variable nomogram predicts invasive pulmonary aspergillosis with moderate accuracy (AUC 0.75) using routine clinical data, aiding early diagnosis.
Candidemia during COVID-19 in a Brazilian hospital was linked to a 19.4% 30-day survival rate, significantly lower than 48.6% in non-COVID cases, indicating worse outcomes.
Nearly half of PCR-identified candidemia cases involve species with presumed fluconazole nonsusceptibility, impacting patient outcomes and treatment strategies.
Scedosporiosis in South India predominantly causes osteomyelitis and sinusitis, with a high mortality rate in severe cases, differing from patterns seen elsewhere.
Clonal isolates of Nakaseomyces glabratus exhibit significant phenotypic variability in stress response and antifungal susceptibility across different patients.
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