Human infections caused by filamentous basidiomycetes: A global systematic review.

In a systematic review of 253 clinically significant human infections by filamentous basidiomycetes, 33 deaths occurred (13.9%), with immune status and histologic invasion independently predicting mortality.

• Why it matters: Clinical spectrum, diagnosis, treatment, susceptibility, and outcomes for these infections remain fragmented, limiting standardized management and interpretation of prognosis across settings.
• What they did: The authors extracted clinical, microbiological, radiological, treatment, susceptibility, and outcome data from 112 studies, compared India (56 cases) versus rest of world (197), and used logistic regression for mortality predictors.
• The result: Immunocompromised status (aOR 7.12; 95% CI 1.44–35.19) and histologic invasion (aOR 3.19; 95% CI 1.10–9.28) predicted mortality, while surgery showed lower observed mortality (aOR 0.07; 95% CI 0.01–0.66) without causality inference.